Reduced P-selectin in Hearts Pretreated with Fluvastatin: A Novel Benefit for Patients Undergoing Open Heart Surgery

Berkan O., Katrancioglu N., Ozker E., Ozerdem G., Bakici Z., YILMAZ M. B.

THORACIC AND CARDIOVASCULAR SURGEON, vol.57, no.2, pp.91-95, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1055/s-2008-1039107
  • Journal Name: THORACIC AND CARDIOVASCULAR SURGEON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.91-95
  • Keywords: coronary bypass surgery, myocardial protection, cardiovascular surgery, fluvastatin, sP-selectin, SOLUBLE ADHESION MOLECULES, PROGRESSION, REDUCTION, ATHEROSCLEROSIS, SIMVASTATIN, PRAVASTATIN, EXPRESSION, PROTECTS, DISEASE, MARKERS
  • Dokuz Eylül University Affiliated: No

Abstract

Objective: P-selectin is an adhesion molecule that plays a role in the pathogenesis of atherosclerosis. The aim of this study was to assess whether or not the treatment with fluvastatin for 3 weeks preoperatively would reduce the levels of circulating P-selectin in patients with coronary heart disease undergoing coronary artery bypass grafting Surgery (CABG).