Ratlarda Kurkuminin Kadmiyum ile İndüklenen Karaciğer Apopitozu Üzerine Koruyucu Etkisi
Bezmiâlem Science, vol.4, no.3, pp.99-105, 2016 (ESCI, TRDizin)
- Publication Type: Article / Article
- Volume: 4 Issue: 3
- Publication Date: 2016
- Doi Number: 10.14235/bs.2016.714
- Journal Name: Bezmiâlem Science
- Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Page Numbers: pp.99-105
- Keywords: Apoptosis, cadmium, curcumin, liver
- Dokuz Eylül University Affiliated: No
Abstract
Objective: Cadmium (CD), which is used for many industrial purposes, is a toxic agent. CD accumulates in the liver; therefore, exposure to toxic doses of Cd results in hepatic damage. Studies in rats have shown that CD induces apoptosis in hepatocytes. Curcumin is a natural compound isolated from Curcuma longa. It has a powerful anti-inflammatory affect and scavenges reactive oxygen radicals. Additionally, it has been shown to have an anti-apoptotic effect in a dose-dependent manner. The aim of the present study was to evaluate the effects of therapeutic doses of curcumin on Cd-induced hepatic apoptosis as well as hepatic biochemical and inflammatory changes in Sprague-Dawley rats.