Ratlarda Kurkuminin Kadmiyum ile İndüklenen Karaciğer Apopitozu Üzerine Koruyucu Etkisi

BAYINDIR N., EŞREFOĞLU M., KUMAŞ M., IRAZ M., KESGİN S., KILIÇ E.

Bezmiâlem Science, cilt.4, sa.3, ss.99-105, 2016 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.14235/bs.2016.714
  • Dergi Adı: Bezmiâlem Science
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.99-105
  • Anahtar Kelimeler: Apoptosis, cadmium, curcumin, liver, INDUCED OXIDATIVE STRESS, ANTIOXIDANT ACTIVITY, ACUTE HEPATOTOXICITY, DEPENDENT PATHWAYS, DNA-REPAIR, CELLS, EXPOSURE, INTERLEUKIN-6, HEPATOCYTES, MECHANISMS
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Objective: Cadmium (CD), which is used for many industrial purposes, is a toxic agent. CD accumulates in the liver; therefore, exposure to toxic doses of Cd results in hepatic damage. Studies in rats have shown that CD induces apoptosis in hepatocytes. Curcumin is a natural compound isolated from Curcuma longa. It has a powerful anti-inflammatory affect and scavenges reactive oxygen radicals. Additionally, it has been shown to have an anti-apoptotic effect in a dose-dependent manner. The aim of the present study was to evaluate the effects of therapeutic doses of curcumin on Cd-induced hepatic apoptosis as well as hepatic biochemical and inflammatory changes in Sprague-Dawley rats.