Comparison of Cisplatin with Lipoplatin in Terms of Ototoxicity

Serinan E., Altun Z. S., AKTAŞ S., Cecen E., Olgun N.

JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, cilt.14, sa.2, ss.211-215, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5152/iao.2018.4097
  • Dergi Adı: JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.211-215
  • Anahtar Kelimeler: Neuroblastoma, Hei-Oc1, lipoplatin, cisplatin, ototoxicity, ACETYL-L-CARNITINE, NEUROBLASTOMA, APOPTOSIS, CELLS, SANGUINARINE, COMBINATION, RADIATION, BIOLOGY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Cisplatin (CDDP) is an anti-neoplastic agent that has been used in treatments of both pediatric and adult cancers. It has many side effects, such as ototoxicity, nephrotoxicity, and neurotoxicity. Lipoplatin (LIPO) is a nanomolecule with 110 nm diameter and composed of lipids and CDDP. In this study, we aimed to compare the toxic effects of LIPO with CDDP in the cochlear cells with anti-tumoral doses determined in neuroblastoma cells.