Comparison of Cisplatin with Lipoplatin in Terms of Ototoxicity


Serinan E., Altun Z. S., AKTAŞ S., Cecen E., Olgun N.

JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, vol.14, no.2, pp.211-215, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.5152/iao.2018.4097
  • Journal Name: JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.211-215
  • Keywords: Neuroblastoma, Hei-Oc1, lipoplatin, cisplatin, ototoxicity, ACETYL-L-CARNITINE, NEUROBLASTOMA, APOPTOSIS, CELLS, SANGUINARINE, COMBINATION, RADIATION, BIOLOGY
  • Dokuz Eylül University Affiliated: Yes

Abstract

OBJECTIVE: Cisplatin (CDDP) is an anti-neoplastic agent that has been used in treatments of both pediatric and adult cancers. It has many side effects, such as ototoxicity, nephrotoxicity, and neurotoxicity. Lipoplatin (LIPO) is a nanomolecule with 110 nm diameter and composed of lipids and CDDP. In this study, we aimed to compare the toxic effects of LIPO with CDDP in the cochlear cells with anti-tumoral doses determined in neuroblastoma cells.