JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, vol.14, no.2, pp.211-215, 2018 (SCI-Expanded)
Article / Article
JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Neuroblastoma, Hei-Oc1, lipoplatin, cisplatin, ototoxicity, ACETYL-L-CARNITINE, NEUROBLASTOMA, APOPTOSIS, CELLS, SANGUINARINE, COMBINATION, RADIATION, BIOLOGY
Dokuz Eylül University Affiliated:
OBJECTIVE: Cisplatin (CDDP) is an anti-neoplastic agent that has been used in treatments of both pediatric and adult cancers. It has many side effects, such as ototoxicity, nephrotoxicity, and neurotoxicity. Lipoplatin (LIPO) is a nanomolecule with 110 nm diameter and composed of lipids and CDDP. In this study, we aimed to compare the toxic effects of LIPO with CDDP in the cochlear cells with anti-tumoral doses determined in neuroblastoma cells.