Akademik Veri Yönetim Sistemi
NAMIK KEMAL MEDICAL JOURNAL, cilt.13, sa.4, ss.367-371, 2025 (ESCI, TRDizin)
Aim: Malignancy, infection, inflammation, liver and renal diseases, hematological disorders, iron overload, metabolic syndrome, and alcohol consumption can cause hyperferritinemia. This study aimed to identify the underlying causes of hyperferritinemia in patients at a tertiary care medical center. Materials and Methods: We retrospectively evaluated the patients with serum ferritin (SF) levels higher than 1000 mu g/L between 2014 and 2016. Among these patients (n=94), 89 patients with hematological disorders (n=69) or oncological diseases (n=20) were included in the study. For patients with multiple SF measurements, the highest level was considered. The association between SF levels and patients' demographics, clinical characteristics, laboratory parameters, and the total number of red blood cell transfusions received were evaluated using the median SF value as a comparison point. Results: The patients' median (min-max) age was 61 (20-94) years, and 49 (55.1%) patients were female. The median (min-max) SF level of the patients' was 1739 mu g/L. Serum aspartate aminotransferase and gamma-glutamyl transferase levels were higher in patients with SF levels above the median value than those with SF below the median (p=0.001, p=0.003, respectively). No significant difference was found in erythrocyte sedimentation rate and C-reactive protein levels between patients with SF levels above the median and those below the median (p=0.689, 0.230, respectively). Patients with SF levels above the median received a higher total number of red blood cell transfusions compared to those with levels below the median (p<0.001). Conclusion: In this study, hematological disorders were the predominant underlying cause of hyperferritinemia potentially due to chronic red blood cell transfusions and inflammation.