Research Information System
ANNALS OF NEUROLOGY, vol.78, no.2, pp.193-210, 2015 (SCI-Expanded, Scopus)
ObjectiveMigraine is among the most common and debilitating neurological conditions. Familial hemiplegic migraine type 1 (FHM1), a monogenic migraine subtype, is caused by gain-of-function of voltage-gated Ca(V)2.1 calcium channels. FHM1 mice carry human pathogenic mutations in the (1A) subunit of Ca(V)2.1 channels and are highly susceptible to cortical spreading depression (CSD), the electrophysiologic event underlying migraine aura. To date, however, the mechanism underlying increased CSD/migraine susceptibility remains unclear.