Abnormal synaptic Ca2+ homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice

Eikermann-Haerter K., Arbel-Ornath M., Yalcin N., Yu E. S., Kuchibhotla K. V., Yuzawa I., ...Daha Fazla

ANNALS OF NEUROLOGY, cilt.78, sa.2, ss.193-210, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 78 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1002/ana.24449
  • Dergi Adı: ANNALS OF NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.193-210
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

ObjectiveMigraine is among the most common and debilitating neurological conditions. Familial hemiplegic migraine type 1 (FHM1), a monogenic migraine subtype, is caused by gain-of-function of voltage-gated Ca(V)2.1 calcium channels. FHM1 mice carry human pathogenic mutations in the (1A) subunit of Ca(V)2.1 channels and are highly susceptible to cortical spreading depression (CSD), the electrophysiologic event underlying migraine aura. To date, however, the mechanism underlying increased CSD/migraine susceptibility remains unclear.