Protective effect of acetyl-l-carnitine against cisplatin ototoxicity: role of apoptosis-related genes and pro-inflammatory cytokines.

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ALTUN Z. S., Olgun Y., Ercetin P., Aktas S., Kirkim G., Serbetcioglu B., ...More

Cell proliferation, vol.47, no.1, pp.72-80, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.1111/cpr.12080
  • Journal Name: Cell proliferation
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.72-80
  • Dokuz Eylül University Affiliated: Yes

Abstract

ObjectivesCisplatin is an anti-neoplastic agent treatment with which causes many side effects including ototoxicity. The aim of this study was to investigate whether acetyl-l-carnitine would have protective effects on cisplatin-induced ototoxicity in vitro, and if present, to reveal roles of apoptotic gene expressions and pro-inflammatory cytokines.