Hypersensitivity to Procarbazine and Severe RSV Pneumonia in a Child with Hodgkin's Lymphoma


İNCE D., Olmez D., Koroglu T. F., Hocaoglu A. B., Camlar S. A., Uysal K. M., ...More

UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, vol.21, no.3, pp.183-187, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.4999/uhod.09090
  • Journal Name: UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.183-187
  • Keywords: Procarbazine, Chemotherapy, Hypersensitivity, Skin reaction, Pulmonary toxicity, Treatment, Child, Respiratory Syncytial virus, Pneumonia, SYNCYTIAL VIRUS-DISEASE, MOPP CHEMOTHERAPY, INFECTION, CANCER, SECONDARY, FEVER
  • Dokuz Eylül University Affiliated: Yes

Abstract

Herein we report respiratory syncytial virus (RSV) pneumonia in a child who had hypersensitivity to procarbazine. Urticarial plaques, maculopapular rash occurred in a child with Hodgkin's lymphoma while receiving procarbazine. Clinical improvement was achieved by withdrawal of procarbazine, administration of corticosteroids, diphenhydramine. After receiving the next course with bleomycin containing chemotherapy, RSV pneumonia developed which required prolonged mechanical ventilation and was treated with oral ribavirin. Hypersensitivity to procarbazine can be a life treating condition. Omitting procarbazine may be necessary. Respiratory syncytial virus pneumonia in the setting of both immunsupression and procarbazine / bleomycin toxicity may have a more serious course.