Hypersensitivity to Procarbazine and Severe RSV Pneumonia in a Child with Hodgkin's Lymphoma

İNCE D., Olmez D., Koroglu T. F., Hocaoglu A. B., Camlar S. A., Uysal K. M., ...Daha Fazla

UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, cilt.21, sa.3, ss.183-187, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.4999/uhod.09090
  • Dergi Adı: UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.183-187
  • Anahtar Kelimeler: Procarbazine, Chemotherapy, Hypersensitivity, Skin reaction, Pulmonary toxicity, Treatment, Child, Respiratory Syncytial virus, Pneumonia, SYNCYTIAL VIRUS-DISEASE, MOPP CHEMOTHERAPY, INFECTION, CANCER, SECONDARY, FEVER
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Herein we report respiratory syncytial virus (RSV) pneumonia in a child who had hypersensitivity to procarbazine. Urticarial plaques, maculopapular rash occurred in a child with Hodgkin's lymphoma while receiving procarbazine. Clinical improvement was achieved by withdrawal of procarbazine, administration of corticosteroids, diphenhydramine. After receiving the next course with bleomycin containing chemotherapy, RSV pneumonia developed which required prolonged mechanical ventilation and was treated with oral ribavirin. Hypersensitivity to procarbazine can be a life treating condition. Omitting procarbazine may be necessary. Respiratory syncytial virus pneumonia in the setting of both immunsupression and procarbazine / bleomycin toxicity may have a more serious course.