Inhibition of nicotine-induced seizures in rats by combining vaccination against nicotine with chronic nicotine infusion

Tunçok Y., Hieda Y., Keyler D., Brown S., Ennifar S., Fattom A., ...Daha Fazla

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, cilt.9, sa.2, ss.228-234, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 2
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1037/1064-1297.9.2.228
  • Dergi Adı: EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.228-234
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The ability of a nicotine vaccine to protect against nicotine-induced seizures was studied in rats. Groups of 10 rats were vaccinated with 3 doses of either a nicotine conjugate vaccine over 6 weeks to elicit high titers of nicotine-specific antibodies or with a control vaccine. Rats were then pretreated with a 1-week subcutaneous infusion of either nicotine 1 mg/kg/day or saline and then received a single 2 mg/kg ip dose of nicotine to provoke seizures. Vaccination reduced the incidence of seizures. The combination of vaccination and pretreatment with nicotine infusion was more effective than either treatment alone. These data suggest that vaccination is protective against this toxic effect of nicotine and that combining vaccination and chronic nicotine administration may provide a novel strategy for blocking some effects of nicotine.