Phylogeographic variation in recombination rates within a global clone of methicillin-resistant Staphylococcus aureus

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Castillo-Ramirez S., Corander J., Marttinen P., Aldeljawi M., Hanage W. P., Westh H., ...More

GENOME BIOLOGY, vol.13, no.12, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 12
  • Publication Date: 2012
  • Doi Number: 10.1186/gb-2012-13-12-r126
  • Journal Name: GENOME BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Next-generation sequencing (NGS) is a powerful tool for understanding both patterns of descent over time and space (phylogeography) and the molecular processes underpinning genome divergence in pathogenic bacteria. Here, we describe a synthesis between these perspectives by employing a recently developed Bayesian approach, BRATNextGen, for detecting recombination on an expanded NGS dataset of the globally disseminated methicillin-resistant Staphylococcus aureus (MRSA) clone ST239.