Phylogeographic variation in recombination rates within a global clone of methicillin-resistant Staphylococcus aureus

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Castillo-Ramirez S., Corander J., Marttinen P., Aldeljawi M., Hanage W. P., Westh H., ...Daha Fazla

GENOME BIOLOGY, cilt.13, sa.12, 2012 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 13 Sayı: 12
• Basım Tarihi: 2012
• Doi Numarası: 10.1186/gb-2012-13-12-r126
• Dergi Adı: GENOME BIOLOGY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Next-generation sequencing (NGS) is a powerful tool for understanding both patterns of descent over time and space (phylogeography) and the molecular processes underpinning genome divergence in pathogenic bacteria. Here, we describe a synthesis between these perspectives by employing a recently developed Bayesian approach, BRATNextGen, for detecting recombination on an expanded NGS dataset of the globally disseminated methicillin-resistant Staphylococcus aureus (MRSA) clone ST239.