CYTOGENETIC FINDINGS IN 21 MALIGNANT MELANOMAS

OZISIK Y., MELONI A., ALTUNGOZ O., PEIER A., KARAKOUSIS C., LEONG S., ...Daha Fazla

CANCER GENETICS AND CYTOGENETICS, cilt.77, sa.1, ss.69-73, 1994 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 77 Sayı: 1
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1016/0165-4608(94)90152-x
  • Dergi Adı: CANCER GENETICS AND CYTOGENETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.69-73
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Cytogenetic analysis was performed on 21 tumor samples of malignant melanoma to identify the presence of consistent chromosome abnormalities. Four cases had a normal karyotype, and 17 were cytogenetically abnormal. Numerical chromosome alterations were observed in 15 tumors: 12 were hyperdiploid and three were hypodiploid. The most frequent losses consisted of chromosomes 5, 9, 17 and Y. The structural abnormalities were usually complex, consisting mainly of nonreciprocal translocations and deletions affecting 1p, 1q, 3p, and 9p. This study adds further data to previously reported melanoma cases, confirming that chromosomes 1, 3, 6, and 9 are nonrandomly affected.