CYTOGENETIC FINDINGS IN 21 MALIGNANT MELANOMAS

OZISIK Y., MELONI A., ALTUNGOZ O., PEIER A., KARAKOUSIS C., LEONG S., ...More

CANCER GENETICS AND CYTOGENETICS, vol.77, no.1, pp.69-73, 1994 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 77 Issue: 1
  • Publication Date: 1994
  • Doi Number: 10.1016/0165-4608(94)90152-x
  • Journal Name: CANCER GENETICS AND CYTOGENETICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Academic Search Premier
  • Page Numbers: pp.69-73
  • Dokuz Eylül University Affiliated: Yes

Abstract

Cytogenetic analysis was performed on 21 tumor samples of malignant melanoma to identify the presence of consistent chromosome abnormalities. Four cases had a normal karyotype, and 17 were cytogenetically abnormal. Numerical chromosome alterations were observed in 15 tumors: 12 were hyperdiploid and three were hypodiploid. The most frequent losses consisted of chromosomes 5, 9, 17 and Y. The structural abnormalities were usually complex, consisting mainly of nonreciprocal translocations and deletions affecting 1p, 1q, 3p, and 9p. This study adds further data to previously reported melanoma cases, confirming that chromosomes 1, 3, 6, and 9 are nonrandomly affected.