Surfactant Protein D as a Novel Therapy for Periventricular Leukomalacia: Is It the Missing Piece of the Puzzle?

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Engur D., Kumral A.

ACS CHEMICAL NEUROSCIENCE, vol.3, no.12, pp.990, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 3 Issue: 12
  • Publication Date: 2012
  • Doi Number: 10.1021/cn300211k
  • Journal Name: ACS CHEMICAL NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.990
  • Keywords: Periventricular leukomalacia, inflammation, toll-like receptor, surfactant protein D, LIPOPOLYSACCHARIDE
  • Dokuz Eylül University Affiliated: No

Abstract

Activation of microglia with an inflammatory insult, which plays a central role in periventricular leukomalacia (PVL), results in premyelinating oligodendrocyte death via release of certain cytokines, reactive oxygen and nitrogen species. Toll-like receptor (TLR) 4 is necessary for lipopolysaccharide (LPS) induced oligodenrocyte injury in the CNS. Having an ability to bind TLR 2, 4, and LPS receptor CD14, surfactant protein D (spD) may be a promising agent to counteract the pathways associated with PVL. Supplementation of surfactant treatment with spD may be the key point in prevention of PVL by supression of inflammation and preventing damage to pre-OLs in a vulnerable premature brain operating through TLRs.