A novel phenalenone-based probe for dual-mode hydrazine detection
Microchemical Journal, cilt.215, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 215
- Basım Tarihi: 2025
- Doi Numarası: 10.1016/j.microc.2025.114263
- Dergi Adı: Microchemical Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Food Science & Technology Abstracts, Index Islamicus, Veterinary Science Database
- Anahtar Kelimeler: Phenalenone, Hydrazine, Fluorescence, Electrochemical detection
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Despite its toxic and carcinogenic nature, hydrazine (N2H4) remains a crucial compound in environmental and industrial applications. Its associated risks demand effective monitoring; however, conventional detection methods often fall short in sensitivity and accuracy, highlighting the need for innovative approaches. This study presents a novel turn-on probe based on phenalenone-phthalimide scaffold, 2-(1-oxo-1H-phenalen-6-yl)isoindoline-1,3-dione (6-AP-PI), specifically designed for N2H4 detection, offering a novel approach by combining fluorescence and electrochemical signals, thereby significantly enhancing detection performance. 6-AP-PI exhibits an exceptional selectivity and sensitivity toward N2H4 both in solution and cellular media, providing rapid signal enhancement (<1 min) and a low limit of detection (490 nM). Overall, this dual-mode design effectively addresses the limitations of traditional methods, enhancing both sensitivity and selectivity, positioning the 6-AP-PI probe as a promising tool for future health, safety, and environmental protection applications.