Akademik Veri Yönetim Sistemi
KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY, cilt.21, sa.1, ss.58-63, 2011 (SCI-Expanded, TRDizin)
Aim: To examine and describe the frequency of cases with drug-induced acute dystonic reactions (ADRs) based on the Data of Dokuz Eylul University Drug and Poison Information Center (DPIC). Method: We analysed drug-induced ADRs and the distribution of the drugs which caused these ADRs reported to Dokuz Eylul University DPIC between January 1993 and December 2008. Statistical analysis was performed using the chi-square test. Results: Of the reported drug-induced ADRs, 81.1% were in children. The female/male ratios were 1.5 and 1.0 in children and adults, respectively. Acute dystonic reactions occurring as side effects of drugs were found to be higher in children between 0 and 12 years of age (87.5%, chi 2=11,285, p= 0.0008). The doses of the drugs to which the patients were exposed were found to be nontoxic (57.7%), unknown (22.3%) or toxic (20.0%). Metoclopramide (44.4%, n=40), haloperidol (35.6%, n=32), risperidone (15.6%, n=14), trifluoperazine (2.2%, n=2), fluphenazine (1%, n=1), and chlorpromazine (1%, n=1) were the drugs that caused the acute dystonic reactions. Metoclopramide (47.9%, n=35) and haloperidol (47.1%, n=8) were the most frequent drugs that caused dystonic reactions in children and adults, respectively. ADRs related to metoclopramide were higher in children between 0 and 12 years of age (chi 2=12,949, p=0.0003). Drug-induced ADRs, that related to nontoxic amount of drugs, were higher in the same age group (chi 2=5,882, p=0.0153). Conclusion: Metoclopramide, haloperidol and risperidone were the most frequent causes of drug-induced ADRs. Physicians should inform patients and their families, when they prescribe haloperidol for adults and metoclopramide for children, about the possibility of drug-induced ADRs even in therapeutic doses.