Radiographic Progression in Ankylosing Spondylitis: From Prognostication to Disease Modification

SARI İ., Haroon N.

CURRENT RHEUMATOLOGY REPORTS, vol.20, no.12, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 12
  • Publication Date: 2018
  • Doi Number: 10.1007/s11926-018-0795-4
  • Journal Name: CURRENT RHEUMATOLOGY REPORTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Spondylarthropathies, Ankylosing spondylitis, Disease progression, Outcomes assessment, Tumor necrosis factor-alpha, Non-steroidal anti-inflammatory agents, Smoking, Diagnostic imaging, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, EARLY AXIAL SPONDYLOARTHRITIS, REDUCES SPINAL INFLAMMATION, TUMOR-NECROSIS-FACTOR, STRUCTURAL DAMAGE, EFFICACY, INFLIXIMAB, SMOKING, BONE, SYNDESMOPHYTES
  • Dokuz Eylül University Affiliated: Yes

Abstract

Purpose of ReviewPain, functional limitation, and spinal damage are the three main domains that have significant impact on various aspects of axial spondyloarthritis (axSpA).Recent FindingsSeveral randomized controlled trials (RCTs) showed a beneficial effect of non-steroid ant-inflammatory drugs (NSAIDs) and biologic treatments on pain and function. The effect of available treatments on spinal damage is still of interest and is being studied.SummaryIn this article, we review the literature on radiographic progression in axSpA. We discuss the natural course of spinal progression, predictors of spinal damage, and the effect of lifestyle changes and medications on radiographic progression in axSpA.