Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma

Sis, B; Sagol, ÖZGÜL; Kupelioglu, A; SÖKMEN, SELMAN; Terzi, C; Fuzun, M; Ozer, E; Bishop, P

doi:10.1016/j.prp.2004.02.012

Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma

Sis B., Sagol Ö., Kupelioglu A., SÖKMEN S., Terzi C., Fuzun M., ...Daha Fazla

PATHOLOGY RESEARCH AND PRACTICE, cilt.200, sa.5, ss.379-387, 2004 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 200 Sayı: 5
Basım Tarihi: 2004
Doi Numarası: 10.1016/j.prp.2004.02.012
Dergi Adı: PATHOLOGY RESEARCH AND PRACTICE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.379-387
Anahtar Kelimeler: matrix metalloproteinase-2, cathepsin-D, tenascin-C, colorectal carcinoma, prognosis
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Matrix metalloproteinase-2 (MMP-2) and cathepsin D (CD) play a significant role in degrading the components of basement membrane and extracellular matrix (ECM), whereas tenascin-C (TN-C) is a glycoprotein of the ECM related to cell adhesion and detachment. These proteins have been implicated in tumor invasion and metastasis. Therefore, we aimed at investigating the prognostic significance of MMP-2, CD, and TN-C expressions in primary colorectal cancer.