Evaluation of the Relationship between Diabetes and Smoking and IL-6, IL-17 and IL-23 Levels in Individuals with Stage II, IV Periodontitis
Meandros Medical And Dental Journal, vol.23, no.4, pp.77-82, 2022 (TRDizin)
- Publication Type: Article / Article
- Volume: 23 Issue: 4
- Publication Date: 2022
- Doi Number: 10.4274/meandros.galenos.2022.54037
- Journal Name: Meandros Medical And Dental Journal
- Journal Indexes: TR DİZİN (ULAKBİM)
- Page Numbers: pp.77-82
- Keywords: Diabetes mellitus, gingival crevicular fluid, interleukin, smoking, periodontitis
- Open Archive Collection: AVESIS Open Access Collection
- Dokuz Eylül University Affiliated: Yes
Abstract
Objective: The purpose of the present investigation was to examine the relationship between diabetes mellitus (DM) and smoking on gingival crevicular fluid (GCF) levels of interleukin (IL)-6, IL-17, and IL-23 in patients with stage II and stage IV periodontitis. Materials and Methods: Individuals were divided into nine groups according to their periodontal diagnosis, smoking, and DM status: periodontally and systemically healthy individuals (PH-H, n=14), periodontally healthy smokers (PH-S, n=14), periodontally healthy diabetics (PH-D, n=14), systemically healthy individuals with stage II periodontitis (SII-H n=14), smokers with stage II periodontitis (SII-S, n=14), diabetics with stage II periodontitis (SII-D, n=14), systemically healthy individuals with stage IV periodontitis (SIV-H, n=14), smokers with stage IV periodontitis (SIV-S, n=14), and diabetics with stage IV periodontitis (SIV-D, n=14). GCF samples were collected and analyzed. Results: The mean GCF levels of IL-6, IL-17, and IL-23 in patients with stage IV periodontitis were significantly higher than those in patients with stage II periodontitis and in periodontally healthy individuals. Conclusion: As the stage of periodontitis increases, the levels of IL-6, IL-17, and IL-23 increase.