Urinary gonadotropin measurements by enhanced luminometric assays (LIA) for the evaluation of pubertal development

Demir A., AYDIN A., Buyukgebiz A., Stenman U., Hero M.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, cilt.34, sa.7, ss.859-866, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 7
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1515/jpem-2020-0598
  • Dergi Adı: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.859-866
  • Anahtar Kelimeler: IFMA, LIA, luteinizing hormone, prepuberty, puberty, serum, urinary gonadotropins, urine, FOLLICLE-STIMULATING-HORMONE, LUTEINIZING-HORMONE, HYPOGONADOTROPIC HYPOGONADISM, PULSATILE SECRETION, FSH, LH, CHILDREN, BOYS, EXCRETION, INCREASE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objectives: Determination of LH in urine has proved to be a reliable method for evaluation of pubertal development. The human LH assay based on time-resolved immunofluorometric (IFMA) technology (AutoDELFIA, PerkinElmer, Wallac) has been found to be suitable for this purpose thanks to its high sensitivity but other assays have not been evaluated. We have analyzed our data obtained by another potentially sensitive detection technique, enhanced luminometric assay (LIA) with the objective of finding a viable alternative to IFMA since these may not be available in the future.