Anatomical MRI abnormalities in bipolar disorder: do they exist and do they progress?

Monkul E., Malhi G., Soares J.

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, vol.39, no.4, pp.222-226, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 4
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1440-1614.2005.01571.x
  • Journal Name: AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.222-226
  • Keywords: bipolar disorder, magnetic resonance imaging, volumetrics, WHITE-MATTER HYPERINTENSITIES, SUBGENUAL PREFRONTAL CORTEX, MAGNETIC-RESONANCE SPECTROSCOPY, CALLOSUM SIGNAL INTENSITY, TEMPORAL-LOBE STRUCTURES, BRAIN GRAY-MATTER, MOOD DISORDERS, HEALTHY-INDIVIDUALS, CINGULATE CORTEX, ADOLESCENT PATIENTS
  • Dokuz Eylül University Affiliated: No

Abstract

Aim: Morphometric brain imaging studies have revealed regional brain abnormalities in patients with bipolar disorder, which may play a role in illness pathophysiology. It is not known whether such changes are of neurodevelopmental, neurodegenerative, or combined origin. We reviewed the anatomical brain imaging literature in bipolar disorder, in an attempt to determine whether there is evidence to suggest that such abnormalities are progressive.