Association of ischemia-modified albumin with oxidative stress status and insulin resistance in obese patients

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Yiğitbaşı T., Başbınar Y., Akgol E., Çalıbaşı Koçal G., Ellidokuz H.

REVISTA ROMANA DE MEDICINA DE LABORATOR, vol.25, no.3, pp.255-263, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.1515/rrlm-2017-0020
  • Journal Name: REVISTA ROMANA DE MEDICINA DE LABORATOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.255-263
  • Keywords: obesity, ischemia-modified albumin, oxidative stress, insulin resistance, TYPE-2 DIABETES-MELLITUS, LIPID-PEROXIDATION, OXIDANT STRESS, WEIGHT-LOSS, HUMAN SERUM, BIOMARKERS, EXERCISE, BINDING, INFLAMMATION, ORLISTAT
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objectives: Obesity is associated with oxidative stress due to the overproduction of free radicals in some accompanying states, such as hyperglycemia, elevated lipid levels and chronic inflammation. Free radical accumulation may modify the structure of human serum albumin, generating ischemia-modified albumin (IMA), and increased serum levels of IMA have been linked to obesity-related diseases and oxidative damage. The association of IMA levels with oxidative stress and insulin resistance (IR) has not been evaluated in the context of obesity. The aim of this study is to determine IMA levels in the context of obesity and their relationship with oxidative status and insulin resistance.