Erythropoietin restores bowel damage and hypoperistalsis in gastroschisis


Ozdamar A., Topcu K., Gumustekin M., Gurel D., Gelal A., Ozer E., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.41, no.2, pp.352-357, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 2
  • Publication Date: 2006
  • Doi Number: 10.1016/j.jpedsurg.2005.11.012
  • Journal Name: JOURNAL OF PEDIATRIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.352-357
  • Keywords: gastroschisis, erythropoietin, gastrointestinal contractility, ALLANTOIC FLUID EXCHANGE, INTESTINAL DAMAGE, NECROTIZING ENTEROCOLITIS, RABBIT MODEL, CONTRACTILITY, PREVENTION, ETIOLOGY, INFANTS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background and Purpose: Despite the decreased mortality in gastroschisis (Gx), patients experience postoperative intestinal hypoperistalsis, malabsorption, and shortened bowel length. The trophic effects of recombinant human erythropoietin (rEpo) in the developing small bowel have been reported, p increasing the length and height of the villi, and villous surface area. This study investigated the effects of rEpo on intestinal malfunction in the chick embryos with Gx.