The relation of serum gamma-glutamyl transpeptidase level and metastasis in renal cell carcinoma

Çinar T., Turgut T., Kirkali Z.

British Journal of Urology, vol.80, pp.123, 1997 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 80
  • Publication Date: 1997
  • Journal Name: British Journal of Urology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.123
  • Dokuz Eylül University Affiliated: Yes


Although Gamma-glutamyl transpeptidase (GOT) is basicly a liver enzyme, recently it has been shown to be localized in the renal proximal tubules The relation of serum GGT with disease status was investigated. Fifty eight of 77 patients who were operated for Renal Cell Carcinoma (RCC) at our institution between June 1989 and 1996 and having preoperative serum GGT values were included The mean GGT value of all cases was 38.9± 5.3 U/L. The mean GGT value of patients with localized RCC was 25.1±2.1 U/L and it was 85.1±21.1 U/L in those having metastatic disease (p<0.02). A significant relation was detected between grade I and III tumors (p<0.02). Serum GGT levels in patients with locally invasive and metastatic disease were higher than of those with localized disease (p<0.02). In the absence of an ideal marker for RCC, serum GGT may have a place in the staging of patients with RCC.