Prevention of peritendinous adhesions following flexor tendon injury with seprafilm

Menderes A., Mola F., Tayfur V., Vayvada H., Barutcu A.

ANNALS OF PLASTIC SURGERY, vol.53, no.6, pp.560-564, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 6
  • Publication Date: 2004
  • Doi Number: 10.1097/
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.560-564
  • Keywords: hyaluronic acid, peritendinous adhesions, tendon repair, SODIUM HYALURONATE, REPAIR, MEMBRANE, MULTICENTER, ACID
  • Dokuz Eylül University Affiliated: Yes


Peritendinous adhesions are the most important complication of flexor tendon injury. In this study, Seprafilm was used for the prevention of peritendinous adhesions following flexor tendon repair. Seprafilm Bioresorbable Membrane (Genzyme Corporation, Cambridge, MA) contains sodium hyaluronate and carboxymethyl cellulose. Thirty New Zealand white male rabbits were divided equally into 3 groups. In all groups, the deep flexor tendon of the third finger of the left back foot was cut and repaired by Kessler-Tajima suture technique. In the first study group following tendon repair, Seprafilm was wrapped around the repaired tendon. In the second study group, sodium hyaluronate gel was injected to the operation field after tendon repair. In the control group, no external material was applied to the field. The study groups had better range of motion. Histopathologically, study groups had less adhesions compared with the control groups. As a result, it was concluded that in rabbit the peritendinous adhesions following flexor tendon repairs could be lowered with Seprafilm and hyaluronic acid.