Endotracheal N-acetylcysteine for Atelectasis in Neonatal Pneumonia

Dilek M., ATASOY H. İ., Acar S.

JOURNAL OF PEDIATRIC RESEARCH, cilt.6, sa.4, ss.359-362, 2019 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4274/jpr.galenos.2019.57442
  • Dergi Adı: JOURNAL OF PEDIATRIC RESEARCH
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.359-362
  • Anahtar Kelimeler: Atelectasis, N-acetylcysteine lavage, newborn, DNASE, LUNG, REDUCTION, VISCOSITY, INFANTS, LAVAGE, VITRO
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Although there is no gold standard therapy in the treatment of atelectasis in newborns, surfactant therapy, inhaled mucolytic agents, recombinant human deoxyribonuclease, positive pressure mechanical ventilation, postural changes and drainage can be used. However, N-acetylcysteine (NAC), via endo-bronchoscopy, is rarely used to break the disulfide bonds in the mucus. It is a cheap and readily available treatment to apply. Here, we present a newborn with neonatal pneumonia to whom we instilled NAC thorough an endotracheal tube to resolve right lung total atetectasis. The atetectasis responded to instillation quickly and successfully. We are presenting this case in order to suggest a novel effective treatment modality for already intubated newborns with atelectasis. This case also represents the first successful treatment case in the newborn period.