The appropriate use of proton pump inhibitors: Single centre experience

TURKISH JOURNAL OF GASTROENTEROLOGY, vol.34, no.5, pp.64-65, 2023 (SCI-Expanded, Scopus, TRDizin)

Publication Type: Article / Abstract
Volume: 34 Issue: 5
Publication Date: 2023
Doi Number: 10.5152/tjg.2023.101123
Journal Name: TURKISH JOURNAL OF GASTROENTEROLOGY
Journal Indexes: Scopus, Science Citation Index Expanded (SCI-EXPANDED), CAB Abstracts, MEDLINE, TR DİZİN (ULAKBİM)
Page Numbers: pp.64-65
Open Archive Collection: AVESIS Open Access Collection
Dokuz Eylül University Affiliated: No

Background/Aims: Proton pump inhibitors (PPIs) are the most

potent gastric acid inhibitors available. Therefore, they are widely

used for the treatment and prevention of acid-related diseases.

Their low side effect profile and frequent use of antiplatelet therapy

or non-steroidal anti-inflammatory drugs (NSAIDs) is also a factor

in this increase. The unnecessary use of PPIs has increased significantly. Therefore, we planned this study to assess the extent to

which indications are followed when prescribing PPIs in both out-ofhospital and hospitalized patients.

Materials and Methods: This was a single-center, cross-sectional

observational study and patients who were hospitalized in the

Gastroenterology Clinic of Mersin University Faculty of Medicine

during the between March 10, 2022-April 10, 2022 were evaluated reasons for hospitalization, other diseases, demographic

data, medications used before hospitalization and treatments

given after hospitalization were recorded by a physician outside

the Gastroenterology clinic. Indications for PPI use: Peptic Ulcer

Disease, GI Bleeding, H.Pylori Eradication, Zollinger Ellison syndrome, Gastroesophageal Reflux Disease (Erosive esophagitis, Non

erosive reflux disease), Functional dyspepsia, NSAIDs in patients

with high risk of GI bleeding, gastroprotection in aspirin/antiplatelet use.

Results: Of the 106 patients in this period, 53% were male and the

mean age was 65.8 years. When PPI use was evaluated: The number

of patients with indication for home use was 24 (22.6%), while the

number of patients using PPIs was 45 (42.4%). While there were 43

(40.5%) patients with indication for use in the hospital, the number

of patients using PPIs in the hospital was 92 (86.7%).

Conclusion: PPIs are valuable drugs in the treatment of acid-related

diseases and have a low side effect profile. This leads to frequent and

unnecessary use of PPIs. This study found that 20% of patients used

unnecessary PPIs at home and nearly half used unnecessary PPIs

even while in the gastroenterology clinic.