Effect of Ecklonia Cava Polyphenol Extract in House Ear Institute-Organ of Corti 1 Cells Against Cisplatin Ototoxicity: A Preliminary Study

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Duzenli U., OLGUN Y., AKTAŞ S., Pamukoglu A., ALTUN Z. S.

TURKISH ARCHIVES OF OTORHINOLARYNGOLOGY, cilt.54, sa.4, ss.141-145, 2016 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5152/tao.2016.1974
  • Dergi Adı: TURKISH ARCHIVES OF OTORHINOLARYNGOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.141-145
  • Anahtar Kelimeler: Cisplatin, ototoxicity, ecklonia cava polyphenol extract (ECP), cochlear cell, RADIATION-INDUCED APOPTOSIS, INDUCED OXIDATIVE STRESS, KOREAN RED GINSENG, ALGAE PHLOROTANNINS, IONIZING-RADIATION, BROWN ALGA, ECKOL, DIECKOL, PHLOROGLUCINOL, DAMAGE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objective: Cisplatin is a widely used agent for the treatment of adult and childhood malignancies. Side effects such as nephrotoxicity, neurotoxicity, and ototoxicity lead to dose limitations. Ecklonia cava polyphenol extract (ECP) is a molecule obtained from algae that live in seawater in the Far East. ECP has recently been shown to have protective effects against oxidative stress. The aim of this study was to evaluate the possible protective effects of ECP on cisplatin ototoxicity.