Effect of Ecklonia Cava Polyphenol Extract in House Ear Institute-Organ of Corti 1 Cells Against Cisplatin Ototoxicity: A Preliminary Study
TURKISH ARCHIVES OF OTORHINOLARYNGOLOGY, vol.54, no.4, pp.141-145, 2016 (ESCI)
- Publication Type: Article / Article
- Volume: 54 Issue: 4
- Publication Date: 2016
- Doi Number: 10.5152/tao.2016.1974
- Journal Name: TURKISH ARCHIVES OF OTORHINOLARYNGOLOGY
- Journal Indexes: Emerging Sources Citation Index (ESCI)
- Page Numbers: pp.141-145
- Keywords: Cisplatin, ototoxicity, ecklonia cava polyphenol extract (ECP), cochlear cell
- Open Archive Collection: AVESIS Open Access Collection
- Dokuz Eylül University Affiliated: Yes
Abstract
Objective: Cisplatin is a widely used agent for the treatment of adult and childhood malignancies. Side effects such as nephrotoxicity, neurotoxicity, and ototoxicity lead to dose limitations. Ecklonia cava polyphenol extract (ECP) is a molecule obtained from algae that live in seawater in the Far East. ECP has recently been shown to have protective effects against oxidative stress. The aim of this study was to evaluate the possible protective effects of ECP on cisplatin ototoxicity.