The Three Sisters of Fate in Multiple Sclerosis: Klotho (Clotho), Fibroblast Growth Factor-23 (Lachesis), and Vitamin D (Atropos)

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Ellidag H. Y., Yilmaz N., Kurtulus F., Aydin O., Eren E., Inci A., ...Daha Fazla

Annals of Neurosciences, cilt.23, 2016 (Hakemli Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1159/000449181
  • Dergi Adı: Annals of Neurosciences
  • Anahtar Kelimeler: Multiple sclerosis, Vitamin D, Klotho, Fibroblast growth factor-23, Choroid plexus, Demyelinization, Oligodendrocyte, BLOOD-BRAIN-BARRIER, CHRONIC KIDNEY-DISEASE, CHOROID-PLEXUS, DIFFERENTIATION, METABOLISM, AXIS, NEURODEGENERATION, EXPRESSION, PROTEIN, STRESS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP). Purpose: This study is aimed at evaluating serum soluble Klt (sKlt), FGF-23, and 25-(OH)-vitamin D levels in multiple sclerosis (MS) patients. Methods: Thirty-two relapsing-remitting MS patients (11 males and 21 females; mean age 38.3 years) and 31 age-sex matched healthy controls (12 males and 19 females; median age 38.5 years) were included in this study. All patients were diagnosed with MS according to the criteria of McDonald. Results: Serum sKlt, FGF-23, and P levels were significantly higher in MS patients compared to the control group (p < 0.01, p < 0.01, and p = 0.02, respectively). Serum 25-(OH)-vitamin D and Ca levels were significantly lower in MS patients (p < 0.01 and p = 0.04, respectively). Conclusion: Klt, which is secreted from CP, could be a response to the press 1 alpha-hydroxylase and upregulates 24 alpha-hydroxylase, which results in a decrease in 1,25-(OH)(2)D-3 levels. Thus, the neuroprotective and immunomodulatory effects of vitamin D might not be seen in MS patients. (C) 2016 S. Karger AG, Basel