Effect of L-carnitine on diabetogenic action of streptozotocin in rats

Uysal Harzadın N., Yalaz G., Acikgoz O., Gonenc S., Kayatekin B. M.

NEUROENDOCRINOLOGY LETTERS, vol.26, no.4, pp.419-422, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 4
  • Publication Date: 2005
  • Journal Name: NEUROENDOCRINOLOGY LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.419-422
  • Keywords: streptozotocin, L-carnitine, superoxide dismutase, glutathione peroxidase, lipid peroxidation, SUPEROXIDE-DISMUTASE COUNTERACTS, LIPID-PEROXIDATION, GLUTATHIONE-PEROXIDASE, DIABETIC RATS, FREE-RADICALS, ANTIOXIDANTS, INCREASE
  • Dokuz Eylül University Affiliated: Yes

Abstract

OBJECTIVES: L-carnitine is a naturally compound widely distributed in the body. It has an antiradical effect and decreases lipid peroxidation. In acute or chronic streptozotocin (STZ)-induced diabetic rats, the pancreatic content of carnitine was found to be significantly lower than nondiabetic group. We investigated the effects of L-carnitine on the development of STZ-induced diabetes in rats, to determine if L-carnitine can prevent the onset of diabetes or reduce the severity of hyperglicemia and this prevention/reduction is associated with the reduction in oxidative stress.