Effect of L-carnitine on diabetogenic action of streptozotocin in rats
NEUROENDOCRINOLOGY LETTERS, vol.26, no.4, pp.419-422, 2005 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 26 Issue: 4
- Publication Date: 2005
- Journal Name: NEUROENDOCRINOLOGY LETTERS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.419-422
- Keywords: streptozotocin, L-carnitine, superoxide dismutase, glutathione peroxidase, lipid peroxidation
- Dokuz Eylül University Affiliated: Yes
Abstract
OBJECTIVES: L-carnitine is a naturally compound widely distributed in the body. It has an antiradical effect and decreases lipid peroxidation. In acute or chronic streptozotocin (STZ)-induced diabetic rats, the pancreatic content of carnitine was found to be significantly lower than nondiabetic group. We investigated the effects of L-carnitine on the development of STZ-induced diabetes in rats, to determine if L-carnitine can prevent the onset of diabetes or reduce the severity of hyperglicemia and this prevention/reduction is associated with the reduction in oxidative stress.