Effect of L-carnitine on diabetogenic action of streptozotocin in rats
NEUROENDOCRINOLOGY LETTERS, cilt.26, sa.4, ss.419-422, 2005 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 4
- Basım Tarihi: 2005
- Dergi Adı: NEUROENDOCRINOLOGY LETTERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.419-422
- Anahtar Kelimeler: streptozotocin, L-carnitine, superoxide dismutase, glutathione peroxidase, lipid peroxidation
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
OBJECTIVES: L-carnitine is a naturally compound widely distributed in the body. It has an antiradical effect and decreases lipid peroxidation. In acute or chronic streptozotocin (STZ)-induced diabetic rats, the pancreatic content of carnitine was found to be significantly lower than nondiabetic group. We investigated the effects of L-carnitine on the development of STZ-induced diabetes in rats, to determine if L-carnitine can prevent the onset of diabetes or reduce the severity of hyperglicemia and this prevention/reduction is associated with the reduction in oxidative stress.