Effect of L-carnitine on diabetogenic action of streptozotocin in rats

Uysal Harzadın N., Yalaz G., Acikgoz O., Gonenc S., Kayatekin B. M.

NEUROENDOCRINOLOGY LETTERS, cilt.26, sa.4, ss.419-422, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 4
  • Basım Tarihi: 2005
  • Dergi Adı: NEUROENDOCRINOLOGY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.419-422
  • Anahtar Kelimeler: streptozotocin, L-carnitine, superoxide dismutase, glutathione peroxidase, lipid peroxidation, SUPEROXIDE-DISMUTASE COUNTERACTS, LIPID-PEROXIDATION, GLUTATHIONE-PEROXIDASE, DIABETIC RATS, FREE-RADICALS, ANTIOXIDANTS, INCREASE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

OBJECTIVES: L-carnitine is a naturally compound widely distributed in the body. It has an antiradical effect and decreases lipid peroxidation. In acute or chronic streptozotocin (STZ)-induced diabetic rats, the pancreatic content of carnitine was found to be significantly lower than nondiabetic group. We investigated the effects of L-carnitine on the development of STZ-induced diabetes in rats, to determine if L-carnitine can prevent the onset of diabetes or reduce the severity of hyperglicemia and this prevention/reduction is associated with the reduction in oxidative stress.