Zn phthalocyanine conjugation to H2-ul aptamer for HER2-targeted breast cancer photodynamic therapy: Design, optimization and properties

Alpugan S., TOPKAYA TAŞKIRAN D., ATİLLA D., AHSEN V., Niazi J. H., DUMOULIN F.

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, vol.21, no.12, pp.887-892, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 12
  • Publication Date: 2017
  • Doi Number: 10.1142/s1088424617500973
  • Journal Name: JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.887-892
  • Keywords: cancer targeting, photodynamic therapy, HER2, aptamer, phthalocyanine
  • Dokuz Eylül University Affiliated: Yes

Abstract

Tetrasulfonated Zn phthalocyanine was conjugated to a ssDNA aptamer moiety to produce a HER2 targeted photosensitizer. The tetraconjugate obtained was subjected to purification and the monoconjugate was successfully isolated, purified and characterized. This monoconjugate retained the ability to bind to HER2 as well as the potency to generate singlet oxygen.