Polymyxin-based photosensitizer for the potent and selective killing of Gram-negative bacteria

ÜÇÜNCÜ, MUHAMMED; Mills, Bethany; Duncan, Sheelagh; Staderini, Matteo; Dhaliwal, Kevin; Bradley, Mark

doi:10.1039/d0cc00155d

Polymyxin-based photosensitizer for the potent and selective killing of Gram-negative bacteria

ÜÇÜNCÜ M., Mills B., Duncan S., Staderini M., Dhaliwal K., Bradley M.

CHEMICAL COMMUNICATIONS, cilt.56, sa.26, ss.3757-3760, 2020 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 56 Sayı: 26
Basım Tarihi: 2020
Doi Numarası: 10.1039/d0cc00155d
Dergi Adı: CHEMICAL COMMUNICATIONS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Communication Abstracts, EMBASE, MEDLINE, DIALNET, Index Chemicus (IC)
Sayfa Sayıları: ss.3757-3760
Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Here we report the synthesis of a novel methylene blue-polymyxin conjugate and demonstrate its light-mediated killing of Gram-negative bacteria on skin models of infection demonstrating a 10(8) decrease in bacterial colony-forming units.