Polymyxin-based photosensitizer for the potent and selective killing of Gram-negative bacteria

Creative Commons License

ÜÇÜNCÜ M., Mills B., Duncan S., Staderini M., Dhaliwal K., Bradley M.

CHEMICAL COMMUNICATIONS, cilt.56, sa.26, ss.3757-3760, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 26
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1039/d0cc00155d
  • Dergi Adı: CHEMICAL COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Communication Abstracts, EMBASE, MEDLINE, DIALNET, Index Chemicus (IC)
  • Sayfa Sayıları: ss.3757-3760
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Here we report the synthesis of a novel methylene blue-polymyxin conjugate and demonstrate its light-mediated killing of Gram-negative bacteria on skin models of infection demonstrating a 10(8) decrease in bacterial colony-forming units.