Otoprotective effect of recombinant erythropoietin in a model of newborn hypoxic-ischemic encephalopathy

OLGUN Y., KIRKIM G., KOLATAN H. E., KİRAY M., BAĞRIYANIK H. A., Serbetcioglu B., ...More

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, vol.77, no.5, pp.739-746, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 77 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.1016/j.ijporl.2013.01.029
  • Journal Name: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.739-746
  • Keywords: Hypoxic-ischemic encephalopathy, Hearing loss, Erythropoietin, POSTNATAL ASPHYXIA, INJURY, INFANTS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: The aim of this study is to test the hypotheses that central auditory pathology as well as inner ear pathology is contributing mechanisms to observed hypoxic-ischemic encephalopathy (HIE) induced hearing loss and that recombinant erythropoietin (rhEPO) will reduce this cellular pathology and attenuate hearing loss.