Otoprotective effect of recombinant erythropoietin in a model of newborn hypoxic-ischemic encephalopathy

OLGUN, YÜKSEL; KIRKIM, GÜNAY; KOLATAN, HATİCE; KİRAY, MÜGE; BAĞRIYANIK, HÜSNÜ; Serbetcioglu, Bulent; YILMAZ, OSMAN; Gokmen, ALİ; ELLİDOKUZ, HÜLYA; KUMRAL, ABDULLAH; SÜTAY, SEMİH

doi:10.1016/j.ijporl.2013.01.029

Otoprotective effect of recombinant erythropoietin in a model of newborn hypoxic-ischemic encephalopathy

OLGUN Y., KIRKIM G., KOLATAN H. E., KİRAY M., BAĞRIYANIK H. A., Serbetcioglu B., ...More

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, vol.77, no.5, pp.739-746, 2013 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 77 Issue: 5
Publication Date: 2013
Doi Number: 10.1016/j.ijporl.2013.01.029
Journal Name: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.739-746
Keywords: Hypoxic-ischemic encephalopathy, Hearing loss, Erythropoietin
Dokuz Eylül University Affiliated: Yes

Abstract

Objective: The aim of this study is to test the hypotheses that central auditory pathology as well as inner ear pathology is contributing mechanisms to observed hypoxic-ischemic encephalopathy (HIE) induced hearing loss and that recombinant erythropoietin (rhEPO) will reduce this cellular pathology and attenuate hearing loss.