Scintigraphic imaging with a peptide glucuronide in rabbits: Tc-99m-exorphin C glucuronide

Ertay T., ÜNAK P., Biber F. Z., Tasci C., ZİHNİOĞLU F., Durak H.

APPLIED RADIATION AND ISOTOPES, cilt.65, sa.2, ss.170-175, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 65 Sayı: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.apradiso.2006.03.017
  • Dergi Adı: APPLIED RADIATION AND ISOTOPES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.170-175
  • Anahtar Kelimeler: exophin C, 99(m)Tc-GE, exophin C glucuronide, 99(m)Tc-GEG, 99(m)Tc-labeled peptides., scintigraphy
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

A peptide glucuronide (Exorphin C glucuronide) was labeled with Tc-99m using glucoheptonate (GH) as a bifunctional chelating agent. Scintigraphic imaging was performed in male Albino rabbits. Exorphin C glucuronide showed rapid and efficient labeling with Tc-99m using glucoheptonate as a bifunctional chelate. Results demonstrated that Tc-99m-GEG may be a useful new type of glucuronide derivative of peptides for diagnosis of some cancer diseases. (c) 2006 Elsevier Ltd. All rights reserved.