Could lysosomal acid lipase enzyme activity be used for clinical follow-up in cryptogenic cirrhosis?

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KÖSE E., Cagatay E., Yaras T., Kisa P., Guler S., Gulten Z. A., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.52, no.4, pp.1075-1084, 2022 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 4
  • Publication Date: 2022
  • Doi Number: 10.55730/1300-0144.5410
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1075-1084
  • Keywords: Cholesterol ester storage disease, cryptogenic cirrhosis, lysosomal acid lipase deficiency, LIPA gene
  • Open Archive Collection: AVESIS Open Access Collection
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background/aim: Cholesterol ester storage disease (CESD) is one of the rare causes that should be kept in mind in the etiology of cirrhosis. Recent studies detected that significantly reduced lysosomal acid lipase deficiency enzyme (LAL) in patients with cryptogenic cirrhosis (CC). Moreover, studies have evaluated that LAL activity is as effective as scoring systems in assessing the severity of cirrhosis.