Akademik Veri Yönetim Sistemi
IZMIR DR BEHCET UZ COCUK HASTANESI DERGISI, cilt.7, sa.1, ss.1-7, 2017 (ESCI, TRDizin)
Antibiotics are the most frequently prescribed drugs in children and antibiotic-associated diarrhea (AAD) is frequently observed in this population. Antibiotic treatment cause different symptoms mostly diarrhea. by impairing resistance of colonization in gastrointestinal flora. In particular, antibiotics with anaerobic activity, such as penicillin, cephalosporin, clindamycin frequently cause diarrhea. Symptoms range from mild clinical findings such as self-limiting diarrhea, to severe particularly Clostiridium difficile associated diarrhea. Antibiotic-associated diarrhea is an important reason for the noncompliance with antibiotic treatment. Probiotics maintain and restore intestinal microecology by improving microbial balance in the intestinal tract with their antibacterial and immune regulatory effects during or after antibiotic treatment. There is growing interest in studies on probiotics and evidence of the effectiveness of probiotics in the prevention and treatment of AAD is also increasing. Despite heterogeneities concerning probiotic strain, dose, duration of use, and the qualities of the studies performed, the evidence obtained supports the protective effect of probiotics in preventing AAD. Nevertheless, further studies are needed to determine which probiotics have the greatest efficacy and for which patients receiving which specific antibiotics. There are limited data regarding the effectiveness of probiotics in the prevention of C. difficile infection in children. There are limited data about the place of probiotics in the treatment of C. difficile infection in adults, and adequate number of studies have not been performed in children about this issue.