Effects of rhG-CSF on neutrophil functions and survival in sepsis induced diabetic rats

Canturk Z., Canturk N., Onen F.

ENDOCRINE RESEARCH, vol.24, no.2, pp.141-157, 1998 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 2
  • Publication Date: 1998
  • Doi Number: 10.1080/07435809809135524
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.141-157
  • Dokuz Eylül University Affiliated: No


Diabetic patients are more prone to infection and evidence for an immunologic defect superimposed upon the metabolic abnormalities of diabetes is convincing. Neutrophils play a critical role in the host defense mechanism against various bacterial infections, and it is suggested that impaired neutrophil functions cause susceptibility to infections in diabetic patients. To explore the possibility that Granulocyte colony-stimulating factor (G-CSF) may be useful to prevent the morbidity and mortality caused by infections in diabetics. We studied the effect of G-CSF against septicemia in diabetic rats.