Prognostic significance of Nestin expression in pT1 high- grade bladder urothelial carcinoma patients treated with intravesical BCG.

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Sen V., BOZKURT O., Demir O., Tuna B., YÖRÜKOĞLU K., ELLİDOKUZ H., ...More

Asian Pacific journal of cancer prevention : APJCP, vol.15, no.24, pp.10813-7, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 24
  • Publication Date: 2014
  • Doi Number: 10.7314/apjcp.2014.15.24.10813
  • Journal Name: Asian Pacific journal of cancer prevention : APJCP
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.10813-7
  • Keywords: Bladder cancer, BCG treatment, response, nestin expression, BACILLE CALMETTE-GUERIN, TRANSITIONAL-CELL CARCINOMA, STAGE T1, URINARY-BLADDER, CANCER, ANGIOGENESIS, MANAGEMENT, INSTILLATION, THERAPY, VESSELS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Possible roles of nestin expression in terms of predicting intravesical BCG therapy response in T1 high grade bladder cancer patients were investigated. Materials and Methods: T1 high grade bladder cancer patients who were treated with intravesical BCG between 1990-2009 were included. Immunohistochemical staining for nestin expression was performed. Nestin(+) and nestin(-) patients were compared in terms of recurrence and progression rates. Results: Sixty-three patients were included and median follow-up time was twenty-five months. After staining; 33 patients (52.4%) were classified as nestin (+) and 30 (47.6%) as (-). Nestin (+) patients were more likely to recur compared to nestin (-) patients (60.6% vs. 30%, p<0.05). Progression rates were also higher in nestin (+) patients, although this result did not reach statistical significance (15.2 % vs. 10 %, p=0.710). Conclusions: Nestin expression, which seems effective in predicting recurrence, appears to have a potential role in the urothelial carcinoma tumorigenesis. Patients with high grade bladder cancer and positive nestin expression need close follow-up and might be informed about more tendency to recur. Further comprehensive studies including larger patient cohorts may clarify the role of nestin in bladder cancer.