Prognostic significance of Nestin expression in pT1 high- grade bladder urothelial carcinoma patients treated with intravesical BCG.

Creative Commons License

Sen V., BOZKURT O., Demir O., Tuna B., YÖRÜKOĞLU K., ELLİDOKUZ H., ...Daha Fazla

Asian Pacific journal of cancer prevention : APJCP, cilt.15, sa.24, ss.10813-7, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 24
  • Basım Tarihi: 2014
  • Doi Numarası: 10.7314/apjcp.2014.15.24.10813
  • Dergi Adı: Asian Pacific journal of cancer prevention : APJCP
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.10813-7
  • Anahtar Kelimeler: Bladder cancer, BCG treatment, response, nestin expression, BACILLE CALMETTE-GUERIN, TRANSITIONAL-CELL CARCINOMA, STAGE T1, URINARY-BLADDER, CANCER, ANGIOGENESIS, MANAGEMENT, INSTILLATION, THERAPY, VESSELS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Possible roles of nestin expression in terms of predicting intravesical BCG therapy response in T1 high grade bladder cancer patients were investigated. Materials and Methods: T1 high grade bladder cancer patients who were treated with intravesical BCG between 1990-2009 were included. Immunohistochemical staining for nestin expression was performed. Nestin(+) and nestin(-) patients were compared in terms of recurrence and progression rates. Results: Sixty-three patients were included and median follow-up time was twenty-five months. After staining; 33 patients (52.4%) were classified as nestin (+) and 30 (47.6%) as (-). Nestin (+) patients were more likely to recur compared to nestin (-) patients (60.6% vs. 30%, p<0.05). Progression rates were also higher in nestin (+) patients, although this result did not reach statistical significance (15.2 % vs. 10 %, p=0.710). Conclusions: Nestin expression, which seems effective in predicting recurrence, appears to have a potential role in the urothelial carcinoma tumorigenesis. Patients with high grade bladder cancer and positive nestin expression need close follow-up and might be informed about more tendency to recur. Further comprehensive studies including larger patient cohorts may clarify the role of nestin in bladder cancer.