EFFECT OF DESMOPRESSIN (DDAVP) ON PROTEIN-C AND PROTEIN-C INHIBITORS IN UREMIA


AKPOLAT T., OZDEMIR O., ARIK N., DEMIRKAN F., SUNGUR C., OZCEBE O., ...Daha Fazla

NEPHRON, cilt.64, sa.2, ss.232-234, 1993 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64 Sayı: 2
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1159/000187319
  • Dergi Adı: NEPHRON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.232-234
  • Anahtar Kelimeler: DESMOPRESSIN, PROTEIN-C ACTIVITY, PROTEIN-C INHIBITORS, UREMIA
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

The effect of desmopressin (DDAVP) on protein C (PC) and PC inhibitors was investigated in 7 uremic predialysis patients, 7 hemodialysis patients and 7 controls. Significant decrease in PC activity was observed in all groups after DDAVP administration. Desmopressin did not influence PC antigen and two well-known PC inhibitors, plasminogen activator inhibitor-3 and alpha1-antitrypsin. Thus, it is suggested that DDAVP-induced decrease in PC activity is not related to the changes in PC inhibitors; further studies are needed to clarify the precise mechanisms of the effect of DDAVP on PC in uremia.