EFFECT OF DESMOPRESSIN (DDAVP) ON PROTEIN-C AND PROTEIN-C INHIBITORS IN UREMIA

AKPOLAT T., OZDEMIR O., ARIK N., DEMIRKAN F., SUNGUR C., OZCEBE O., ...More

NEPHRON, vol.64, no.2, pp.232-234, 1993 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 2
  • Publication Date: 1993
  • Doi Number: 10.1159/000187319
  • Journal Name: NEPHRON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.232-234
  • Keywords: DESMOPRESSIN, PROTEIN-C ACTIVITY, PROTEIN-C INHIBITORS, UREMIA
  • Dokuz Eylül University Affiliated: No

Abstract

The effect of desmopressin (DDAVP) on protein C (PC) and PC inhibitors was investigated in 7 uremic predialysis patients, 7 hemodialysis patients and 7 controls. Significant decrease in PC activity was observed in all groups after DDAVP administration. Desmopressin did not influence PC antigen and two well-known PC inhibitors, plasminogen activator inhibitor-3 and alpha1-antitrypsin. Thus, it is suggested that DDAVP-induced decrease in PC activity is not related to the changes in PC inhibitors; further studies are needed to clarify the precise mechanisms of the effect of DDAVP on PC in uremia.