With the fourth industrial revolution emerging as a requirement of the global production network, companies and countries are connected more tightly through supply chain networks around the world. The fourth industrial revolution "Industry 4.0" means that all innovations in digital technology mature, especially in the manufacturing sector, during the transformation process. These technologies are especially advanced internet, artificial intelligence and robotics, advanced sensor technology, cloud technology that accelerates data transfer and utilization, digital fabrication (3D printing), new services and marketing models, smart phones, and algorithms for navigation tools, delivery and ride services and autonomous vehicles. All these elements are included in the global value chain so that they can be shared by many companies from many countries. So, in the fourth industrial revolution, there are different technologies that are brought together for different but the same purpose. It is therefore becoming more complex to organize global organizations that are global, interconnected, and international. Industry 4.0 brings new dimensions both qualitative and quantitative within the companies that have used the new automation technologies for years and have experience and knowledge. Industry 4.0 has a complex nature beyond the modern production management system (MES) and world class production (WCM). The aim of this study is to show that the concept of project management in the Industry 4.0 approach, where large-scale physical and virtual worlds are tried to be brought together, is particularly affected by this change in the manufacturing sector. With this study, it is stated that changing the project management approach is a necessity. Moreover, this interaction is also discussed for industrial facilities.