Research Information System
2025 Annual Congress of Schizophrenia International Research Society, Illinois, United States Of America, 29 March - 02 April 2025, pp.11, (Summary Text)
Background: Clinical-High-Risk for psychosis (CHR-P) is an important concept in identifying the potential prodromal phase of psychotic disorder. CHR-P is associated with significant functional impairment and cognitive deficits. Recently, a smaller number of studies investigated clinical-high-risk for bipolar disorder (CHR-BD). However, unlike chronic stages, the early phase of schizoaffective disorders has not been the focus of available studies. In this study, we aimed the characteristics of investigate at-risk subjects who meet the criteria of both CHR-P and CHR-BD (CHR-Mixed Psychoses (CHR-MP)) compared to at-risk subjects meeting only one of these high-risk states.
Methods: This study included 89 youth with CHR-P, 65 with CHR-BD and 36 CHR-MP. Structured clinical interviews for at risk for psychosis and bipolar disorder, the Personal and Social Performance Scale and a comprehensive battery including processing speed, verbal memory, visual memory, working memory, executive functions, attention and social cognition were administered to all participants.
Results: There were significant differences for clinical, social functioning, neurocognition and social cognition between groups. CHR-MP had more negative symptoms, social functional and neurocognitive impairment compared to CHR-BD. Neurocognitive differences were particularly significant for verbal memory (p < 0.001) and processing speed (p < 0.001). In general, the cognitive profile of CHR-MP was intermediate between CHR-BD and CHR-P. At follow-up, UHR-MP was associated with conversion to both first-episode psychosis (FEP) and first-episode bipolar disorder (FEBD). In contrast, CHR-BD and CHR-P groups did only convert to expected diagnoses (CHR-BD to FEBD and CHR-P to FEP).
Discussion: The clinical, functional and cognitive profile of CHR-MP lies between CHR-P and CHR-BD. CHR-MP might be the early stage of schizoaffective disorder and related mixed psychotic-affective presentations. Follow-up studies are needed to establish long-term prognosis of cases CHR-MP.