Efficacy of Topical Brinzolamide Treatment in Posterior Microphthalmos-Related Macular Cystoid Lesions: A Case Series.

Durmaz E. C., Baran E. U., SELVER M. A., Saatçi A. O.

Turkish journal of ophthalmology, vol.50, no.1, pp.44-49, 2020 (Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.4274/tjo.galenos.2019.40504
  • Journal Name: Turkish journal of ophthalmology
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.44-49
  • Keywords: Brinzolamide, macular cystoid lesion, retinoschisis, posterior microphthalmos, PAPILLOMACULAR FOLD, CARBONIC-ANHYDRASE, DORZOLAMIDE, RETINOSCHISIS, MANAGEMENT, FEATURES, EDEMA
  • Dokuz Eylül University Affiliated: Yes


The aim of this study was to report the outcome of topical brinzolamide 1% treatment on macular cystoid lesions resembling retinoschisis in 4 patients diagnosed with posterior microphthalmia. The medical records of 4 patients with a clinical diagnosis of posterior microphthalmia who had started topical brinzolamide 1% treatment were reviewed. Visual acuity, central foveal thickness, and cystoid lesion area percentage were used to evaluate treatment response. In the follow-up, there was a decrease in central foveal thicknesses and cystoid lesion area percentages in both eyes of 3 of the patients. However, 1 patient showed increases in both parameters. Visual acuity remained stable in 5 eyes and increased in 3 eyes. Topical brinzolamide treatment may have some positive effects on macular cystoid lesions in selected cases.