Cytosine Methyltransferases as Tumor Markers

Pavlopoulou A., Kossida S.

CURRENT GENOMICS, cilt.11, sa.8, ss.568-577, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 8
  • Basım Tarihi: 2010
  • Doi Numarası: 10.2174/138920210793360916
  • Dergi Adı: CURRENT GENOMICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.568-577
  • Anahtar Kelimeler: Biomarkers, cancer, chromatin modification, CpG methylation, DNMTs, epigenetic therapy, oncogenes, tumor suppressor genes, HISTONE DEACETYLASE INHIBITORS, CPG-ISLAND METHYLATION, BINDING PROTEIN MECP2, DNA METHYLATION, CANCER-CELLS, DE-NOVO, SUPPRESSOR GENES, SILENCED GENES, TRANSCRIPTIONAL REPRESSOR, MYELODYSPLASTIC SYNDROME
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Changes in DNA methylation patterns is a prominent characteristic of human tumors. Tumor cells display reduced levels of genomic DNA methylation and site-specific CpG island hypermethylation. Methylation of CpG dinucleotides is catalyzed by the enzyme family of DNA methyltransferases (DNMTs). In this review, the role of DNA methylation and DNMTs as key determinants of carcinogenesis is further elucidated. The chromatin modifying proteins that are known to interact with DNMTs are also described. Finally, the role of DNMTs as potential therapeutic targets is addressed.