Lung clearance of aerosolized Tc-99m erythromycin lactobionate in rabbits

Durak H., Ertay T., Sayit E., Aktogu S., Kut O., Guven H., ...More

NUCLEAR MEDICINE AND BIOLOGY, vol.23, no.3, pp.291-293, 1996 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 3
  • Publication Date: 1996
  • Doi Number: 10.1016/0969-8051(95)02080-2
  • Journal Name: NUCLEAR MEDICINE AND BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.291-293
  • Keywords: alveolar macrophage, erythromycin, lung imaging, radionuclide imaging, radioaerosols, INCREASES
  • Dokuz Eylül University Affiliated: Yes

Abstract

In order to assess the lung clearance of aerosolized Tc-99m Erythromycin Lactobionate (EL), Tc-99m EL was administered to 9 New Zealand rabbits by inhalation. 5 rabbits inhaled cigarette smoke before Tc-99m EL. Clearance half times were 3.0 +/- 0.9 hours in normals, 5.5 +/- 1.0 hours after smoke exposure. Clearance was not affected after destroying the surfactant layer. Slower clearance after smoke exposure may be due to the inhibition of mucociliary clearance. Tc-99m EL can be considered as an alternative radioaerosol for ventilation imaging.