Vitamin D in Childhood Cancer: A Promising Anticancer Agent?

Genc D. B., ÖZKAN M. H., Buyukgebiz A.

PEDIATRIC ENDOCRINOLOGY REVIEWS PER, cilt.10, sa.4, ss.485-493, 2013 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 4
  • Basım Tarihi: 2013
  • Dergi Adı: PEDIATRIC ENDOCRINOLOGY REVIEWS PER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.485-493
  • Anahtar Kelimeler: Vitamin D, childhood cancer, prevention, treatment
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Children diagnosed and treated for cancer are vulnerable to Vitamin D deficiency depending on many factors. The Vitamin D status in children with cancer has been mostly regarded as a contributory factor for skeletal pathologies so far. However, the calcitriol was found to promote cell differentiation, inhibit malignant proliferation, and exhibit anti-inflammatory, proapoptotic and antiangiogenic properties. In Addition to this, numerous epidemiological studies link Vitamin D and cancer and indicate to possible role of Vitamin D in cancer pathogenesis and progression. This article aims to provide an overview of the possible role of Vitamin D deficiency in childhood cancer in terms of prevention and treatment.