The Effect of Cisplatin Toxicity and Capsaicin on Electron Transport Chain in Liver and Kidney of Sprague Dawley Rats


Kursunluoglu G., AYAR KAYALI H., TAŞKIRAN D.

CELL BIOCHEMISTRY AND BIOPHYSICS, vol.69, no.3, pp.707-716, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 3
  • Publication Date: 2014
  • Doi Number: 10.1007/s12013-014-9857-z
  • Journal Name: CELL BIOCHEMISTRY AND BIOPHYSICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.707-716
  • Keywords: Cisplatin, Capsaicin, ETC, CAT, LPO, ATP, ADP, LIPID-PEROXIDATION, INDUCED NEPHROTOXICITY, OXIDATIVE STRESS, APOPTOSIS, HEPATOTOXICITY, CHEMOTHERAPY, ANTIOXIDANTS, MECHANISM, MEMBRANE, SELENIUM
  • Dokuz Eylül University Affiliated: Yes

Abstract

Cisplatin accumulates in mitochondria, which is a potent and widely used chemotherapeutic agent. In order to clarify the potential effect of cisplatin on electron transport chain (ETC), the variation of succinate dehydrogenase (SDH) and cytochrome c oxidase (COX) enzyme activities, nucleotide levels, as well as catalase (CAT) enzyme and membrane lipid peroxidation (LPO) level with respect to liver and kidney of cisplatin-exposed rats were studied. We found that cisplatin caused significant impairment in the SDH, COX, and CAT activities, and nucleotide levels associated with membrane LPO in isolated mitochondria. It was determined whether capsaicin, as an antioxidant, has a possible protective role on all investigated parameters of liver and kidney induced by cisplatin. The results of capsaicin + cisplatin suggest that capsaicin have antioxidant capacity to scavenge ROS to prevent membrane damage.