Effects of carbon dioxide exposure on early brain development in rats

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Kiray M., Sisman A., Camsari U. M., Evren M., Dayı A., Baykara B., ...Daha Fazla

BIOTECHNIC & HISTOCHEMISTRY, cilt.89, sa.5, ss.371-383, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 89 Sayı: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3109/10520295.2013.872298
  • Dergi Adı: BIOTECHNIC & HISTOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.371-383
  • Anahtar Kelimeler: air quality, amygdala, carbon dioxide, hippocampus, insulin-like growth factor-1, IGF-1, learning, memory, prefrontal cortex, PREFRONTAL CORTEX, IGF-1 LEVELS, VENTILATORY PHYSIOLOGY, MATERNAL-DEPRIVATION, OXIDATIVE STRESS, INDUCED ANXIETY, NEURON DENSITY, INJURY, INVOLVEMENT, INHALATION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The developing brain is vulnerable to environmental factors. We investigated the effects of air that contained 0.05, 0.1 and 0.3% CO2 on the hippocampus, prefrontal cortex (PFC) and amygdala. We focused on the circuitry involved in the neurobiology of anxiety, spatial learning, memory, and on insulin-like growth factor-1 (IGF-1), which is known to play a role in early brain development in rats. Spatial learning and memory were impaired by exposure to 0.3% CO2 air, while exposure to 0.1 and 0.3% CO2 air elevated blood corticosterone levels, intensified anxiety behavior, increased superoxide dismutase (SOD) enzyme activity and MDA levels in hippocampus and PFC; glutathione peroxidase (GPx) enzyme activity decreased in the PFC with no associated change in the hippocampus. IGF-1 levels were decreased in the blood, PFC and hippocampus by exposure to both 0.1 and 0.3% CO2. In addition, apoptosis was increased, while cell numbers were decreased in the CA1 regions of hippocampus and PFC after 0.3% CO2 air exposure in adolescent rats. A positive correlation was found between the blood IGF-1 level and apoptosis in the PFC. We found that chronic exposure to 0.3% CO2 air decreased IGF-1 levels in the serum, hippocampus and PFC, and increased oxidative stress. These findings were associated with increased anxiety behavior, and impaired memory and learning.