Phase-stable Doppler OCT at 19 MHz using a stretched-pulse mode-locked laser

TOZBURUN S., Blatter C., Siddiqui M., Meijer E. F. J., Vakoc B. J.

BIOMEDICAL OPTICS EXPRESS, cilt.9, sa.3, ss.952-961, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1364/boe.9.000952
  • Dergi Adı: BIOMEDICAL OPTICS EXPRESS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.952-961
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

We present a swept-wavelength optical coherence tomography (OCT) system with a 19 MHz laser source and electronic phase-locking of the source, acquisition clock, and beam scanning mirrors. The laser is based on stretched-pulse active mode-locking using an electro-optic modulator. Beam scanning in the fast axis uses a resonant micro-electromechanical systems (MEMS) -based mirror at similar to 23.8 kHz. Acquisition is performed at 1.78 Gigasamples per second using an external fixed clock. Phase sensitive imaging without need for k-clocking, A-line triggers, or phase-calibration methods is demonstrated. The system was used to demonstrate inter-frame and inter-volume Doppler imaging in the mouse ear and brain at 4D acquisition rates of 1, 30, 60 and 100 volumes/sec (V-scans/s). Angiography based on inter-frame and inter-volume methods are presented. The platform offers extremely fast and phase-stable measurements that can be used in preclinical angiographic and Doppler investigations of perfusion dynamics. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement