Evaluation of Liposomal and Microbubbles Mediated Delivery of Doxorubicin in Two-Dimensional (2D) and Three-Dimensional (3D) Models for Breast Cancer

Aydin M., Ozdemir E., Altun Z. S., Kilic S., Aktaş S.

EUROPEAN JOURNAL OF BREAST HEALTH, cilt.17, sa.3, ss.274-282, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.4274/ejbh.galenos.2021.6255
  • Dergi Adı: EUROPEAN JOURNAL OF BREAST HEALTH
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.274-282
  • Anahtar Kelimeler: 3D cell culture, breast cancer, doxorubicin, liposome, microbubble, DRUG-DELIVERY, ULTRASOUND, THERAPY, CELLS, TARGET
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objective: Liposomal cancer treatment strategies are useful in removing the side effects that were the main concern in recent years. In this study, we prepared microbubble (MBs) conjugated with DOX-loaded liposomes (DOX-loaded MBs) and investigated their effectiveness in in vitro breast cancer cells in two dimensions (2D) and three dimensions (3D).