Evaluation of Liposomal and Microbubbles Mediated Delivery of Doxorubicin in Two-Dimensional (2D) and Three-Dimensional (3D) Models for Breast Cancer

Aydin M., Ozdemir E., Altun Z. S., Kilic S., Aktaş S.

EUROPEAN JOURNAL OF BREAST HEALTH, vol.17, no.3, pp.274-282, 2021 (ESCI, Scopus, TRDizin) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.4274/ejbh.galenos.2021.6255
  • Journal Name: EUROPEAN JOURNAL OF BREAST HEALTH
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.274-282
  • Keywords: 3D cell culture, breast cancer, doxorubicin, liposome, microbubble
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: Liposomal cancer treatment strategies are useful in removing the side effects that were the main concern in recent years. In this study, we prepared microbubble (MBs) conjugated with DOX-loaded liposomes (DOX-loaded MBs) and investigated their effectiveness in in vitro breast cancer cells in two dimensions (2D) and three dimensions (3D).