Methamphetamine causes lipid peroxidation and an increase in superoxide dismutase activity in the rat striatum

Acikgoz, OSMAN; Gonenc, SEVİL; Kayatekin, BERKANT; Uysal Harzadın, NAZAN; Pekcetin, ÇETİN; Semin, I; Gure, A

doi:10.1016/s0006-8993(98)01020-8

Methamphetamine causes lipid peroxidation and an increase in superoxide dismutase activity in the rat striatum

Acikgoz O., Gonenc S., Kayatekin B. M., Uysal Harzadın N., Pekcetin Ç., Semin I., ...Daha Fazla

BRAIN RESEARCH, cilt.813, sa.1, ss.200-202, 1998 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 813 Sayı: 1
Basım Tarihi: 1998
Doi Numarası: 10.1016/s0006-8993(98)01020-8
Dergi Adı: BRAIN RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.200-202
Anahtar Kelimeler: dopamine, methamphetamine, reactive oxygen species, superoxide dismutase, lipid peroxidation, striatum
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The administration of methamphetamine to experimental animals results in damage to nigrostriatal dopaminergic neurons. In the present study, we demonstrated that both the acute repeated and the chronic administration of methamphetamine causes an increase in thiobarbituric acid reactive substances, which are indicators of lipid peroxidation, and superoxide dismutase activity in the rat striatum. The results of present study strengthen the notion that reactive oxygen species may play an important role in the methamphetamine-induced neurotoxicity. (C) 1998 Elsevier Science B.V. All rights reserved.