Methamphetamine causes lipid peroxidation and an increase in superoxide dismutase activity in the rat striatum

Acikgoz O., Gonenc S., Kayatekin B. M., Uysal Harzadın N., Pekcetin Ç., Semin I., ...More

BRAIN RESEARCH, vol.813, no.1, pp.200-202, 1998 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 813 Issue: 1
  • Publication Date: 1998
  • Doi Number: 10.1016/s0006-8993(98)01020-8
  • Journal Name: BRAIN RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.200-202
  • Keywords: dopamine, methamphetamine, reactive oxygen species, superoxide dismutase, lipid peroxidation, striatum, GLUTATHIONE-PEROXIDASE, OXIDATIVE STRESS, BRAIN, DOPAMINE, CATECHOLAMINES, NEUROTOXICITY, SYNAPTOSOMES, EXPRESSION, RELEASE, CELLS
  • Dokuz Eylül University Affiliated: Yes

Abstract

The administration of methamphetamine to experimental animals results in damage to nigrostriatal dopaminergic neurons. In the present study, we demonstrated that both the acute repeated and the chronic administration of methamphetamine causes an increase in thiobarbituric acid reactive substances, which are indicators of lipid peroxidation, and superoxide dismutase activity in the rat striatum. The results of present study strengthen the notion that reactive oxygen species may play an important role in the methamphetamine-induced neurotoxicity. (C) 1998 Elsevier Science B.V. All rights reserved.