Angiotensin receptor-neprilysin inhibition by sacubitril/valsartan attenuates doxorubicin-induced cardiotoxicity in a pretreatment mice model by interfering with oxidative stress, inflammation, and Caspase 3 apoptotic pathway

Dindas F., GÜNGÖR H., EKİCİ M., Akokay P., ERHAN F., Dogdus M., ...More

ANATOLIAN JOURNAL OF CARDIOLOGY, vol.25, no.11, pp.821-828, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 11
  • Publication Date: 2021
  • Doi Number: 10.5152/anatoljcardiol.2021.356
  • Journal Name: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.821-828
  • Keywords: sacubitril, valsartan, doxorubicin, cardiotoxicity, heart failure, INDUCED CARDIOMYOPATHY, CANCER-THERAPY, TNF-ALPHA, ADRIAMYCIN, DYSFUNCTION, ARRHYTHMIAS, MECHANISMS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: Doxorubicin (DOX) is a well-known cardiotoxic agent, whereas sacubitril/valsartan (Sac/Val) is an effective treatment option in heart failure. In this study, we aimed to evaluate the effect of Sac/Val on DOX-induced cardiotoxicity in pretreatment mice model.