Gemcitabine combined with infusional 5-fluorouracil and high-dose leucovorin for the treatment of advanced carcinoma of the pancreas

Oztop İ., Yilmaz U., YAVUZŞEN T., Yaren A., Tarhan O., Sagol Ö., ...Daha Fazla

CHEMOTHERAPY, cilt.50, sa.3, ss.127-132, 2004 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1159/000077886
  • Dergi Adı: CHEMOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.127-132
  • Anahtar Kelimeler: advanced pancreatic cancer, 5-fluorouracil, gemcitabine
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: 5-Fluorouracil (5-FU) and gemcitabine are the major active drugs in the treatment of pancreatic cancer. Methods: Twenty-two patients with advanced pancreas cancer were treated with a new chemotherapy regimen consisting of infusional 5-FU and high-dose leucovorin with gemcitabine (GEMFUFOL). Results: A total of 200 cycles of chemotherapy were administered. The response rate was 27.3%, all responses being partial. The median survival time and 1-year survival rate were, respectively, 13 months and 60.4%. The toxicity was very low and severe hematological toxicity was exceptional. Conclusion: The GEMFUFOL regimen can be an active regimen for the treatment of advanced pancreatic cancer and has a low toxicity. Copyright (C) 2004 S. Karger AG, Basel.