Impact of antibiotic resistance on outcomes of neutropenic cancer patients with Pseudomonas aeruginosa bacteraemia (IRONIC study): study protocol of a retrospective multicentre international study

Albasanz-Puig, Adaia; Gudiol, Carlota; Parody, Rocio; Tebe, Cristian; AKOVA, MURAT; Araos, Rafael; Bote, Anna; Brunel, Anne-Sophie; Calik, Sebnem; Drgona, Lubos; Garcia, Estefania; Hemmati, Philipp; Herrera, Fabian; Ibrahim, Karim; Isler, Burcu; Kanj, Souha; Kern, Winfried; Maestro de la Calle, Guillermo; Manzur, Adriana; Ivan Marin, Jorge; Marquez-Gomez, Ignacio; Martin-Davila, Pilar; Mikulska, Malgorzata; Montejo, Jose; Montero, Milagros; Paz Morales, Hugo; Morales, Isabel; Novo, Andres; Oltolini, Chiara; Peghin, Maddalena; Luis del Pozo, Jose; Puerta-Alcalde, Pedro; Ruiz-Camps, Isabel; Resat Sipahi, Oguz; Tilley, Robert; Yanez, Lucrecia; Ribeiro Gomes, Marisa; Carratala, Jordi; Cuervo, Guillermo; Escrihuela-Vidal, Francesc; Tubau, Fe; Rodriguez Arias, Marisol; Merve Ayaz, Caglayan; Munita, Jose; Gasch, Oriol; Capilla, Silvia; Bochud, Pierre-Yves; Manuel, Oriol; Torre-Cisneros, Julian; Tabares, Salvador; Serrano Lopez, Josefina; Maschmeyer, Georg; Torres, Diego; Abdala, Edson; Bittencourt, Driele; El Zein, Saeed; Jabbour, Jean-Francois; Bertz, Hartmut; Peyerl-Hoffmann, Gabriele; Lizasoain, Manuel; Maria Aguado, Jose; Clemencia Correa, Lina; Palop, Begona; Fortun, Jesus; Magnasco, Laura; Cespedes, Roberto; Lopez-Soria, Leire; Pablo Horcajada, Juan; Montaguti, Mia; de Cueto, Marina; Rodriguez-Bano, Jesus; Greco, Raffaella; Cichero, Paola; Bassetti, Matteo; Castaldo, Nadia; Sangro del Alcazar, Paloma; Cardozo, Celia; Garcia-Vidal, Carolina; Aguilar-Company, Juan; Larrosa, Nieves; Uyan-Onal, Ayse; NAZLI ZEKA, ARZU; Vasconcelos de Freitas, Wania; da Silva Machado, Amanda

doi:10.1136/bmjopen-2018-025744

Impact of antibiotic resistance on outcomes of neutropenic cancer patients with Pseudomonas aeruginosa bacteraemia (IRONIC study): study protocol of a retrospective multicentre international study

Albasanz-Puig A., Gudiol C., Parody R., Tebe C., AKOVA M., Araos R., ...More

BMJ OPEN, vol.9, no.5, 2019 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 9 Issue: 5
Publication Date: 2019
Doi Number: 10.1136/bmjopen-2018-025744
Journal Name: BMJ OPEN
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Open Archive Collection: AVESIS Open Access Collection
Dokuz Eylül University Affiliated: Yes

Abstract

Introduction Pseudomonas aeruginosa (PA) has historically been one of the major causes of severe sepsis and death among neutropenic cancer patients. There has been a recent increase of multidrug-resistant PA (MDRPA) isolates that may determine a worse prognosis, particularly in immunosuppressed patients. The aim of this study is to establish the impact of antibiotic resistance on the outcome of neutropenic onco-haematological patients with PA bacteraemia, and to identify the risk factors for MDRPA bacteraemia and mortality.